A Second Challenging Opportunity for Obesity Researchers
Prof. Dr. Mohamed Elhashemy
August 25, 2009
A modified stamp-sized 'micro-needle' patch when applied to the gastric fundus mucosa may curb hunger through boosting Elhashemy´s Stomach Satiety Spot "ESSS".
It may be the most suitable and least troubling invention that curbs hunger in over-eater obese people.
In August 2009, Dr. Mark Prausnitz and colleagues, of the Georgia Institute of Technology in Atlanta, U.S.A, invented a stamp-sized patch which is studded with dozens of tiny needles (each is about a millimeter long) that may help painless injections. The aim of such patch, when coated with medicine, is to takes the pain out of injections.
In August 2009, a scientific research published online by the journal Science revealed that scientists have pinpointed a type of nerve cell in mice which appears to generate the itch sensation.
I wrote an article on American Chronicle titled: "A Challenging Opportunity for Obesity Researchers" in which I said that: if researchers find a way to manipulate the neurons in gastric fundus mucosa, the same way they manipulated the neurons that are itch-specific, they may detect that these gastric fundus neurons are satiety-specific
I considered this research a Challenging Opportunity for Obesity Researchers to prove the existence of "ESSS".
Using the same principle, I believe that obesity researchers can apply a patch similar to that used by Dr. Prausnitz for skin injections but modified to suit the gastric fundus mucosa. The main required modification will be to make the patch with a curved smooth edge in order to not hurt the mucosa of the stomach during its contractions. I expect that when researchers apply this patch to mice they will detect that mice will become constantly satiated i.e. hypophagic.
The reason behind my expectation is that the patch will create continuous irritation of "ESSS" area, thus leading to continuous stomach satiety sensation, which in turn leads to lower food intake and consequently significant loss of body weight of the experimented mice.
If this experiment proved successful it will lead to:
1. Assurance of presence of ESSS, a hypothesis developed by me on June 2008.
2. Invention of The Fundus Patch which may be introduced to the gastric cavity through fine gastroscope and attached to the gastric wall through its micro-needles at the "ESSS" area. The latter may boost activity of vagal nerve endings especially when gastric muscles contract upon it.
This invention will be of great help to obese who refrain from various bariatric surgeries with their complications, since it may induce the same beneficial effects without such complications.
It may be the most suitable and least troubling invention that curbs hunger in over-eater obese people.
In August 2009, Dr. Mark Prausnitz and colleagues, of the Georgia Institute of Technology in Atlanta, U.S.A, invented a stamp-sized patch which is studded with dozens of tiny needles (each is about a millimeter long) that may help painless injections. The aim of such patch, when coated with medicine, is to takes the pain out of injections.
In August 2009, a scientific research published online by the journal Science revealed that scientists have pinpointed a type of nerve cell in mice which appears to generate the itch sensation.
I wrote an article on American Chronicle titled: "A Challenging Opportunity for Obesity Researchers" in which I said that: if researchers find a way to manipulate the neurons in gastric fundus mucosa, the same way they manipulated the neurons that are itch-specific, they may detect that these gastric fundus neurons are satiety-specific
I considered this research a Challenging Opportunity for Obesity Researchers to prove the existence of "ESSS".
Using the same principle, I believe that obesity researchers can apply a patch similar to that used by Dr. Prausnitz for skin injections but modified to suit the gastric fundus mucosa. The main required modification will be to make the patch with a curved smooth edge in order to not hurt the mucosa of the stomach during its contractions. I expect that when researchers apply this patch to mice they will detect that mice will become constantly satiated i.e. hypophagic.
The reason behind my expectation is that the patch will create continuous irritation of "ESSS" area, thus leading to continuous stomach satiety sensation, which in turn leads to lower food intake and consequently significant loss of body weight of the experimented mice.
If this experiment proved successful it will lead to:
1. Assurance of presence of ESSS, a hypothesis developed by me on June 2008.
2. Invention of The Fundus Patch which may be introduced to the gastric cavity through fine gastroscope and attached to the gastric wall through its micro-needles at the "ESSS" area. The latter may boost activity of vagal nerve endings especially when gastric muscles contract upon it.
This invention will be of great help to obese who refrain from various bariatric surgeries with their complications, since it may induce the same beneficial effects without such complications.
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